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A redesigned cancer immunotherapy is showing striking early results after decades of disappointment with similar drugs. Researchers engineered a more powerful CD40 agonist antibody and changed how it’s delivered—injecting it directly into tumors instead of into the bloodstream. In a small clinical trial of 12 patients with metastatic cancers, six saw their tumors shrink and two experienced complete remission.
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ScienceDaily
An East Bay apartment complex has been bought at a price that's well below its prior value. Read more ›
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A PG&E Corp. unit has bought a San Jose building in a move to bolster the utility's South Bay operations. Read more ›
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Вы уверены, что ваш “случайный” пароль действительно случайный?Я тоже так думал — пока не полез разбираться, как Python на самом деле генерирует случайные значения. Оказалось, что привычный random — это не про безопасность вообще. Это генератор, который только выглядит случайным, но при определённых условиях может быть воспроизведён. Что даст нам возможность предсказать все будущие пароли и прошлые.В статье я последовательно разбираю: • почему классическая “энтропия пароля” часто вводит в заблуждение;... Read more ›
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A report that the U.S. and Iran are discussing a 45-day ceasefire lifted risk assets across the board on Monday, with short liquidations outpacing longs nearly 3-to-1 in the past 12 hours. Read more ›
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The funniest people in the room aren't always processing their pain — some learned early to use humor as perimeter control, setting the tone for how their suffering is received so nobody else can decide it's worse than they're prepared to admit. Read more ›
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What do you need out of your EDC (everyday carry) earbuds? Monster battery life? Is 46 hours good enough? Active noise cancellation? We'd say up to 50dB of noise reduction is great! Strong sound quality? The Honor Earbuds 4 gives you dual titanium-coated drivers. Smart features? You get both press and swipe controls, like on some much more expensive offerings. Not bad. Now the price? Roughly $50-$70 (€45–€70), though they're... Read more ›
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Если тема управления задачами в Obsidian вам близка - заглядывайте в мой тг-канал, там я разбираю подобные вещи регулярно. Читать далее Read more ›
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You don't need to spend a fortune to get a great floor cleaning gadget — these are the best affordable options I've tested. Read more ›
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Самые интересные новости финансов и технологий в России и мире за неделю: лимит на зарубежный инет-трафик в России, банковская инфраструктура РФ поломалась на день, IPO SpaceX целит уже на $2 трлн, OpenAI купили подкаст для псиопов, а у Claude Code утек исходный код. Читать далее Read more ›
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After its 18-month fast forward, InterGlobe-owned European hotel brand Miiro is hitting pause to make sure guests actually want to come back. Read more ›
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OpenAI CEO Sam Altman and CFO Sarah Friar are diverging over the company’s timeline for an initial public offering as Altman pushes for a public debut as early as the fourth quarter, The Information reported. Friar has privately expressed concerns that the AI startup will not be ... Read more ›
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A lot of genuinely smart people don’t walk around thinking, I’m intelligent. In fact, some of the sharpest people I’ve met tend to underestimate themselves. They’re not always the loudest person in the room. They’re not always the most impressive on paper, either. They might not have the fanciest job title, the highest grades, or ... Read more Read more ›
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Кто давно читает публикуемые здесь материалы, тот знает про мой интерес к мозгу, психике и вопросу о продуктивности. Когда речь заходит о продуктивности, то возникает закономерный вопрос: могу ли я что-то принять, чтобы быть умнее, сосредоточеннее, усидчивее? С одной стороны, у нас уже есть кофе, который бодрит, но есть ли что-то более фундаментальное? Да, есть. Но то, как работают базовые «смарт-таблетки», не влияет на интеллект, и не улучшает качество когнитивных... Read more ›
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NASA's Artemis astronauts are now entering "the lunar sphere of influence," reports NBC News, "meaning the pull of the moon's gravity will become stronger than Earth's." Now as they begin their swing around the moon, the Artemis astronauts "are chasing after Apollo 13's maximum range from Earth," reports the Associated Press, hoping to beat its distance from Earth by more than 4,100 miles (6,600 kilometers). They'll begin their six-hour lunar... Read more ›
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US forces ditched the aircraft and then bombed them to prevent them from falling into Iranian hands, multiple Western outlets have reported. Read more ›
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I waited three years to start writing. Not because I didn’t want to. I wanted to desperately. I had ideas. I had things to say. I had a vague but persistent sense that writing was the thing I was supposed to be doing with my life. But every time I sat down to begin, something ... Read more Read more ›
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The billionaire said that they can either tear their companies down and rebuild with AI or do nothing. Either way, shareholders won't be happy. Read more ›
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Anthropic's head of growth, Amol Avasare, said the AI lab has such an open culture that employees can give feedback to top leadership. Read more ›
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It took years, but blood pressure monitoring is finally arriving for Galaxy Watch users in the US. Read more ›
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ScienceDaily
Just a few minutes of getting out of breath each day could dramatically cut your risk of major diseases—including heart disease, dementia, and diabetes. A large study of nearly 100,000 people found that it’s not just how much you move, but how intensely you move that matters. Short bursts of vigorous activity—like rushing for a bus or climbing stairs quickly—were linked to striking reductions in disease risk, especially for inflammatory... Read more ›
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A powerful cholesterol-lowering drug may be changing the rules of heart disease prevention. Researchers found that evolocumab, typically used for people who already have cardiovascular disease, can significantly cut the risk of first-time heart attacks and strokes in high-risk patients with diabetes—even before any artery-clogging plaque is detected. Read more ›
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A large U.S. study reveals that more than a quarter of people with hard-to-treat high blood pressure may have an overlooked hormone problem. Elevated cortisol—often linked to stress—was found in 27% of these patients, far higher than expected. This hidden condition could explain why standard medications fail. The discovery could lead to new testing and treatments that finally help bring blood pressure under control. Read more ›
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A blazing supermassive black hole can influence far more than its own galaxy. Scientists found that quasars emit radiation strong enough to shut down star formation in nearby galaxies millions of light-years away. This could explain why some galaxies near early quasars appear faint or missing. The finding suggests galaxies grow and evolve together, not in isolation. Read more ›
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Astronomers have spotted a bizarre cosmic explosion that refuses to play by the rules—and it’s leaving scientists scrambling for answers. GRB 250702B, detected by NASA’s James Webb Space Telescope and a global network of observatories, lasted an astonishing seven hours—far longer than typical gamma-ray bursts, which usually fade in under a minute. Read more ›
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A major analysis of nearly 10,000 patients shows that simple, non-drug treatments like knee braces, hydrotherapy, and exercise can significantly ease knee osteoarthritis symptoms. These approaches not only reduce pain and improve mobility, but also avoid the risks tied to common medications. The findings suggest that low-cost, accessible therapies could play a bigger role in how doctors treat arthritis in the future. Read more ›
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Certain smaller sauropods could stand on their hind legs with surprising ease, giving them access to higher food and a defensive edge. Computer simulations show their bones handled stress better than those of their larger relatives. However, as they grew, the sheer weight made this posture much harder to sustain. What started as a useful trick in youth became a more limited, strategic move in adulthood. Read more ›
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Scientists have discovered something that seems almost impossible: under the right conditions, ordinary liquids can snap apart like solid objects. In experiments, researchers found that when certain liquids are stretched with enough force, they don’t just thin and flow—they suddenly fracture with a sharp break, much like metal under stress. This surprising behavior appears to be tied to viscosity, not elasticity, challenging long-held assumptions about how liquids behave. Read more ›
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Deep sleep does far more than rest the body — it activates a powerful brain-driven system that controls growth hormone, fueling muscle and bone strength, metabolism, and even mental performance. Scientists have now mapped the neural circuits behind this process, uncovering a delicate feedback loop in which sleep boosts growth hormone, and that same hormone helps regulate wakefulness. Read more ›
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Scientists at the University of Waterloo have uncovered a bold new way to explain how the universe began—one that could reshape our understanding of the Big Bang. Instead of relying on patched-together theories, their approach shows that the universe’s explosive early growth may arise naturally from a deeper framework called quantum gravity. Read more ›
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06.04.2026 01:37
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