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351 Inflammation turns bone marrow into a breeding ground for disease

ScienceDaily
ScienceDaily · 11/19/2025 10:21 EDT

Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon-responsive T cells create a self-sustaining inflammatory loop that weakens blood production. Surprisingly, the mutant cells themselves may not be the main instigators.

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