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832 Depression may start with an energy problem in brain cells

ScienceDaily
ScienceDaily · 03/12/2026 07:09 EDT

Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy molecules at rest but had trouble increasing energy production when needed. Scientists believe this imbalance may contribute to symptoms such as fatigue and low motivation. The finding could help pave the way for earlier diagnosis and more personalized treatments.

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