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Researchers have uncovered the enzyme behind chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers. The enzyme, N4BP2, breaks apart DNA trapped in tiny cellular structures, unleashing a burst of genetic changes that can help tumors rapidly adapt and resist therapy. Blocking the enzyme dramatically reduced this genomic destruction in cancer cells.
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ScienceDaily
An East Bay apartment complex has been bought at a price that's well below its prior value. Read more âș
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A PG&E Corp. unit has bought a San Jose building in a move to bolster the utility's South Bay operations. Read more âș
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Extra virgin olive oil might help protect your brain by working through your gut. A two-year study found that people who consumed it had better cognitive performance and more diverse gut bacteria than those using refined olive oil. Researchers even identified specific microbes linked to these benefits. The findings suggest that choosing high-quality olive oil could be a simple way to support brain health as you age. Read more âș
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Looking to ride safer and smarter? This Californian program delivers hands-on training and real benefits that make it worth a closer look. Read more âș
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After decades of drowning out their inner voice with career demands and family obligations, people in their early 60s finally encounter silenceâand discover the person thinking their thoughts feels like a complete stranger. Read more âș
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Last May Duolingo's stock peaked at $529.05. But while the learning app passed $1 billion in revenue in 2025 and 50 million daily active users, today its stock price has dropped more than 81%, to $100.51. And there's been other changes, reports Entrepreneur: In April 2025, Duolingo CEO Luis von Ahn made headlines after writing a memo calling the company "AI-first." In the memo, von Ahn announced that the language-learning... Read more âș
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Watching your parents age isn't one devastating blowâit's a thousand paper cuts of grief that arrive in the smallest moments, from repeated stories to trembling signatures, each one a tiny goodbye to the person they used to be. Read more âș
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Earlier this week, vivo announced the start of the global rollout of the X300 Ultra and X300 FE with the exact date depending on the market â itâs April 24 for Spain, for example. Also, the X300 Ultra is now up on Amazon with an eye-watering price tag of âŹ2,000 (16GB/1TB). Based on the results from last weekâs poll, the vivo X300 Ultra will be one of the main challengers... Read more âș
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Before buying a washing machine, you want to make sure it is well-rated by real-world users. This customer satisfaction survey ranked the best brands. Read more âș
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The laugh that arrives before the painful part of a story isn't a sign of healing. It's a social contract, written in real time, that releases the listener from having to respond seriously â a skill learned from people who cou Read more âș
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The best movies on Amazon Prime Video this month include Pretty Lethal, The Bluff, Super 8, The Great Escape, Sinners, and more. Read more âș
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The NYT Strands hints and answers you need to make the most of your puzzling experience. Read more âș
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Connections is a New York Times word game that's all about finding the "common threads between words." How to solve the puzzle. Read more âș
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Connections: Sports Edition is a New York Times word game about finding common sports threads between words. How to solve the day's puzzle. Read more âș
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The New York Times' latest game, Pips, brings domino fun to your desktop. How to play Pips as well as hints in case you get stuck. Read more âș
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Here's the answer for "Wordle" #1765 on April 19 as well as a few hints, tips, and clues to help you solve it yourself. Read more âș
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Fully electric vehicles are the new hotness, but hybrids still have their place in the market. Here are some common hybrid battery issues drivers run into. Read more âș
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After Artemis II's astronauts returned to earth, "NASA has Artemis III in its sights," reports the Associated Press: In a mission recently added to the docket for next year, Artemis III's yet-to-be -named astronauts will practice docking their Orion capsule with a lunar lander or two in orbit around Earth. Elon Musk's SpaceX and Jeff Bezos' Blue Origin are racing to have their company's lander ready first. Musk's Starship and... Read more âș
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With the weather starting to warm, you may be feeling the itch to start a new project. One of these tools from Lowe's could be helpful additions for that. Read more âș
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ĐŃŃŃ ŃĐ°ĐșĐ°Ń ŃŃŃĐșĐ°, ĐșĐ°Đș "ĐŽĐžŃплДĐč ĐżĐŸĐșŃпаŃДлŃ" - ŃŃĐŸ ŃĐŸŃ ŃĐ°ĐŒŃĐč ŃĐșŃĐ°Đœ ĐœĐ° ĐșĐ°ŃŃĐ”, гЎД пОŃŃŃ ŃĐșĐŸĐ»ŃĐșĐŸ ĐŽĐ”ĐœĐ”Đł ĐČŃ ĐŽĐŸĐ»Đ¶ĐœŃ Đ·Đ°ĐżĐ»Đ°ŃĐžŃŃ. Đ Đ”ŃŃŃ ŃĐ°ĐșĐŸĐ” ĐœĐ°ŃĐŸĐŽĐœĐŸĐ” ŃĐ°Đ·ĐČлДŃĐ”ĐœĐžĐ” - ЎДлаŃŃ ĐžĐ· ŃŃĐžŃ ŃĐșŃĐ°ĐœĐŸĐČ ĐČŃŃĐșĐŸĐ” ŃĐ°Đ·ĐœĐŸĐ” - ĐœŃ ĐœĐ°ĐżŃĐžĐŒĐ”Ń, "ŃĐ°ŃŃ ĐžĐ»Đž ĐŒĐ”ŃĐ”ĐŸŃŃĐ°ĐœŃĐžŃ" (Ń)ЀОŃĐșĐ° ŃŃŃ ĐČ ŃĐŸĐŒ, ŃŃĐŸ ĐŒĐŸĐ¶ĐœĐŸ ĐżŃĐžĐŸĐ±ŃĐ”ŃŃĐž ĐžŃ Đ±/Ń Đ·Đ° ĐșĐŸĐżĐ”ĐčĐșĐž, Đž ĐżĐŸĐ»ŃŃĐžŃŃ ĐżŃĐž ŃŃĐŸĐŒ ĐČĐžĐœŃĐ°Đ¶ĐœŃĐč ĐłĐ°Đ·ĐŸŃĐ°Đ·ŃŃĐŽĐœŃĐč ŃĐșŃĐ°Đœ, ĐżŃĐžŃŃĐœĐŸĐłĐŸ Đ·Đ”Đ»Đ”ĐœĐŸĐłĐŸ ОлО ŃĐžĐœĐ”ĐłĐŸ ŃĐČĐ”ŃĐ°. ĐŃŃŃŃ Đ°Đ»ŃĐ°ĐČĐžŃĐœĐŸ-ŃĐžŃŃĐŸĐČĐŸĐč - ĐŽĐ»Ń ŃĐ°ŃĐŸĐČ ŃŃĐŸĐłĐŸ Đ±ĐŸĐ»Đ”Đ” ŃĐ”ĐŒ ĐŽĐŸŃŃĐ°ŃĐŸŃĐœĐŸ.... Read more âș
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ScienceDaily
A major international effort has produced an ultra-precise measurement of the Universeâs expansion rate, confirming itâs faster than early-Universe models predict. By linking multiple distance-measuring techniques, scientists ruled out simple errors as the cause of the discrepancy. The persistent âHubble tensionâ now looks more real than ever. It could mean our current model of the cosmos is incomplete. Read more âș
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Mars may be hostile, but it might not be entirely unlivable. In lab experiments, yeast cells survived simulated Martian shock waves and toxic perchlorate saltsâtwo major environmental threats on the Red Planet. Their secret weapon was forming protective molecular clusters that shield critical cellular functions under stress. Without these defenses, survival plummeted, pointing to a potential universal strategy life could use beyond Earth. Read more âș
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A new nanodisc-based platform lets scientists study viral proteins in a form that closely mimics real viruses, revealing how antibodies truly recognize them. This approach uncovered hidden interactions in viruses like HIV and Ebola that traditional methods missed. By recreating the virusâs membrane environment, researchers can better understand how immune defenses work. The technique could speed up the development of more effective vaccines. Read more âș
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Researchers are launching a new project to crack the mystery of aggressive breast cancer, where predicting disease progression remains a major hurdle. By studying how tumors interact with and suppress the immune system, scientists aim to identify new biomarkers that reveal how the cancer evolves. Using real patient samples, the team hopes to turn earlier discoveries into practical clinical tools. The goal: more precise, personalized treatments that can outsmart even... Read more âș
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The first-ever published research on Tinshemet Cave reveals that Neanderthals and Homo sapiens in the mid-Middle Paleolithic Levant not only coexisted but actively interacted, sharing technology, lifestyles, and burial customs. These interactions fostered cultural exchange, social complexity, and behavioral innovations, such as formal burial practices and the symbolic use of ochre for decoration. The findings suggest that human connections, rather than isolation, were key drivers of technological and cultur Read more âș
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A cave in Belgium has revealed unsettling evidence that Neandertals selectively cannibalized outsiders, focusing on women and children. The victims werenât from the local group and appear to have been treated like prey, with bones butchered for meat and marrow. This suggests the behavior wasnât ritual, but practicalâor possibly linked to intergroup conflict. The discovery paints a darker, more complex picture of Neandertal life during their final millennia. Read more âș
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A new study reveals that popular diabetes and weight-loss drugs like Ozempic and Wegovy may not work as effectively for about 10% of people due to specific genetic variants. These individuals appear to have a puzzling condition called âGLP-1 resistance,â where their bodies produce higher levels of the hormone targeted by these drugsâbut donât respond to it properly. Read more âș
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A newly discovered molecule could reshape the future of weight loss treatments by mimicking the powerful appetite-suppressing effects of drugs like Ozempic â but without many of the unpleasant side effects. Identified using artificial intelligence, this tiny peptide, called BRP, appears to act directly on the brainâs appetite-control center, helping animals eat less and lose fat without nausea or muscle loss. Read more âș
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A twice-yearly injection may soon change how high blood pressure is treated. In a global trial, patients receiving the experimental drug zilebesiran alongside standard therapy saw greater blood pressure reductions than those on standard treatment alone. The drug works by blocking a key liver protein, helping blood vessels relax. Researchers say this long-lasting approach could make it much easier for patients to keep their condition under control. Read more âș
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A colossal âcosmic volcanoâ has erupted in deep space, as a supermassive black hole in galaxy J1007+3540 roars back to life after nearly 100 million years of silence. Astronomers captured stunning radio images showing fresh jets blasting outward while crashing into the intense pressure of a surrounding galaxy cluster, creating a chaotic, distorted structure stretching nearly a million light-years. Read more âș
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19.04.2026 00:03
Last update: 23:55 EDT.
News rating updated: 06:50.
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