150 place 4

378 A hidden brain energy signal drives depression and anxiety

ScienceDaily
ScienceDaily · 11/26/2025 02:53 EDT

Scientists discovered that lowered brain energy signaling in the hippocampus can lead to both depression- and anxiety-like behaviors in mice. Stress reduced ATP, a molecule important for cell energy and communication. Altering a protein called connexin 43, which helps release ATP, caused similar symptoms even without stress. Restoring this protein improved mood-related behavior.

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