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A cutting-edge approach to immunotherapy shows that forcing cancer cells to die through necroptosis can dramatically boost the body's anti-tumor defenses. By combining three existing drugs, scientists reprogrammed malignant B cells so they release danger signals that rally immune cells to fully eliminate leukemia in preclinical models.
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ScienceDaily
In his inauguration speech, Mayor Zohran Mamdani doubled down on campaign promises, pledging to "govern expansively and audaciously." Read more ›
3,965 fresh
From 'Jujutsu Kaisen' to 'Frieren: Beyond Journey's End,' here are the anime to watch in the new year. Read more ›
299 fresh
Costco's consistency -- from its $1.50 hot dog and drink combo to its functional shopping carts and satisfied employees -- has produced what The Atlantic calls a "cultlike loyalty" among members at more than 600 locations across the U.S. Its annual membership costs $65. The model traces back to Fedco, a nonprofit wholesale collective for federal employees founded in Los Angeles in the 1940s. Costco's private label Kirkland Signature has... Read more ›
262 fresh
Afters years of talk, governments in Australia, France, and more are taking action to ban social-media for kids. Some warn of unintended effects. Read more ›
203 fresh
An anonymous reader shares a report: Only the government could spend 20 years creating a national ID that no one wanted and that apparently doesn't even work as a national ID. But that's what the federal government has accomplished with the REAL ID, which the Department of Homeland Security (DHS) now considers unreliable, even though getting one requires providing proof of citizenship or lawful status in the country. In a... Read more ›
198 fresh
A new record-high clock speed has been achieved on AMD's Ryzen 7 9800X3D. The best gaming CPU in the world doesn't need to be overclocked to achieve exceptional performance, but Chinese overclocker "Hero" has just pushed it to 7,335 MHz using a Colorful iGame X870E Vulcan motherboard, using liquid nitrogen. Read more ›
189 fresh
Chirp wellness, founded by Tate Stock, grew from $450 and a barn to $250 million in sales, pivoting from yoga wheels to pain relief tools. Read more ›
168 fresh
St. Barthelemy, or St. Barts, is a French-speaking Caribbean island with beaches and high-end shops where billionaires like Jeff Bezos vacation. Read more ›
145 fresh
Every human body contains a small population of cells that are not genetically its own -- cells that crossed the placenta during pregnancy and that persist for decades after birth. These "microchimeric" cells, named after the lion-goat-serpent hybrid of Greek mythology, have been found in every organ studied so far, though they are exceedingly rare: one such cell exists for every 10,000 to 1 million of a person's own cells.... Read more ›
132 fresh
On January 1, 1983, ARPANET system architects initiated the cutover from the existing NCP to TCP/IP on all hosts. Read more ›
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The billionaire gifted Tesla shares worth nearly $100 million to charities in connection with "year-end tax planning," according to an SEC filing. Read more ›
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Jeff Bezos owns more than $200 million of real estate in Miami. A vacant plot next to him just sold for $105 million. Read more ›
111 fresh
Double-detonating "superkilonova," Roman liquid gypsum burials, biomechanics of kangaroo posture, and more. Read more ›
108 fresh
A new year means new Marvel shows to watch, and the first to come in 2026 is 'Wonder Man.' Read more ›
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Some years ago, I was writing a science fiction short story in which I wanted to incorporate verses from a 1928 song, "Button Up Your Overcoat." However, when I sold the story, my editor told me that since the song was still copyrighted, it was safer not to include the verses. If I had written […] Read more ›
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As usual, 2025 was a year of deep congressional dysfunction in the US. But state legislatures were passing laws that govern everything from AI to social media to the right to repair. Many of these laws, alongside rules passed in past years, take effect in 2026 - either right now or in the coming months. […] Read more ›
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Early versions of Betty Boop, Pluto, and Mickey and Minnie Mouse are on the list. Read more ›
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The U.S. Department of Commerce didn't renew the validated end-user status of these chipmakers, requiring them to acquire annual licenses to import chipmaking tools containing U.S. tech into their Chinese fabs. Read more ›
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ScienceDaily
UBC Okanagan researchers have uncovered how plants create mitraphylline, a rare natural compound linked to anti-cancer effects. By identifying two key enzymes that shape and twist molecules into their final form, the team solved a puzzle that had stumped scientists for years. The discovery could make it far easier to produce mitraphylline and related compounds sustainably. It also highlights plants as master chemists with untapped medical potential. Read more ›
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Researchers have created a protein that can detect the faint chemical signals neurons receive from other brain cells. By tracking glutamate in real time, scientists can finally see how neurons process incoming information before sending signals onward. This reveals a missing layer of brain communication that has been invisible until now. The discovery could reshape how scientists study learning, memory, and brain disease. Read more ›
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A new randomized trial from Vanderbilt-Ingram Cancer Center reveals that magnesium may be the missing key to keeping vitamin D levels in balance. The study found that magnesium raised vitamin D in people who were deficient while dialing it down in those with overly high levels—suggesting a powerful regulating effect. This could help explain why vitamin D supplements don’t work the same way for everyone and why past studies linking... Read more ›
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Scientists discovered that common food emulsifiers consumed by mother mice altered their offspring’s gut microbiome from the very first weeks of life. These changes interfered with normal immune system training, leading to long-term inflammation. As adults, the offspring were more vulnerable to gut disorders and obesity. The findings suggest that food additives may have hidden, lasting effects beyond those who consume them directly. Read more ›
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The Arctic is changing rapidly, and scientists have uncovered a powerful mix of natural and human-driven processes fueling that change. Cracks in sea ice release heat and pollutants that form clouds and speed up melting, while emissions from nearby oil fields alter the chemistry of the air. These interactions trigger feedback loops that let in more sunlight, generate smog, and push warming even further. Together, they paint a troubling picture... Read more ›
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MIT researchers have designed a printable aluminum alloy that’s five times stronger than cast aluminum and holds up at extreme temperatures. Machine learning helped them zero in on the ideal recipe in a fraction of the time traditional methods would take. When 3D printed, the alloy forms a tightly packed internal structure that gives it exceptional strength. The material could eventually replace heavier, costlier metals in jet engines, cars, and... Read more ›
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A major breakthrough in battery science reveals why promising single-crystal lithium-ion batteries haven’t lived up to expectations. Researchers found that these batteries crack due to uneven internal reactions, not the grain-boundary damage seen in older designs. Even more surprising, materials thought to be harmful actually helped the batteries last longer. The discovery opens the door to smarter designs that could dramatically extend battery life and safety. Read more ›
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Environmental change doesn’t affect evolution in a single, predictable way. In large-scale computer simulations, scientists discovered that some fluctuating conditions help populations evolve higher fitness, while others slow or even derail progress. Two populations facing different kinds of change can end up on completely different evolutionary paths. The findings challenge the idea that one population’s response can represent a whole species. Read more ›
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A shiny gray crystal called platinum-bismuth-two hides an electronic world unlike anything scientists have seen before. Researchers discovered that only the crystal’s outer surfaces become superconducting—allowing electrons to flow with zero resistance—while the interior remains ordinary metal. Even stranger, the electrons on the surface pair up in a highly unusual pattern that breaks all known rules of superconductivity. Read more ›
42
Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone emergency fix that helps them survive. Some cancer cells rely heavily on this backup system, even though it makes their DNA more unstable. Blocking this process could expose a powerful new way to target tumors. Read more ›
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Business Insider
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Tom's Hardware
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Slashdot
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Financial Times
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6% 6 |
CNET
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5% 3 |
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01.01.2026 19:14
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