CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known 'gene scissor' but is much smaller and thus easier to transport into cells. Using protein engineering and AI algorithms, researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the... Read more ›
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Children born during the pandemic, including those exposed to COVID in utero, were no more likely to screen positive for autism than unexposed or pre-pandemic children. Read more ›
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A new method for relocating proteins that have been misplaced in cells could mean new treatments for cancers and neurodegeneration. Read more ›
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Researchers found that X-rays of the kidneys using gold nanoparticles as a contrast agent might be more accurate in detecting kidney disease than standard laboratory blood tests. Read more ›
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A new, wide-ranging exploration of human remains casts doubt on a long-standing theory in archaeology known as the Kurgan hypothesis -- which, among other claims, suggests that humans first domesticated horses as early as the fourth millennium B.C. Read more ›
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Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -- in a particular subset of T cells -- cause mitochondrial stress, DNA damage and cell death, researchers have discovered. The findings offer a mechanistic understanding for how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer. Read more ›
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A research team has developed a computational workflow for analyzing large data sets in the field of metabolomics, the study of small molecules found within cells, biofluids, tissues, and entire ecosystems. Read more ›
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Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic. Read more ›
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The Colorado River is a vital source of water in the Western United States, providing drinking water for homes and irrigation for farms in seven states, but the basin is under increasing pressure from climate change and drought. A new computational tool may help the region adapt to a complex and uncertain future. Read more ›
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Researchers have shown that they can generate a strong immune response against HIV with two doses of a vaccine given one week apart. Read more ›
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Investigators developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely to work for each individual patient. By using 3D mini tumor models that closely resemble a patient's tumor, treatments could be tailored more effectively, paving the way for more personalized cancer treatments. Read more ›
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First used in the 1940s to monitor for polio, wastewater surveillance proved such a powerful disease monitoring tool that the U.S. Centers for Disease Control and Prevention (CDC) established the National Wastewater Surveillance System to support SARS-CoV-2 monitoring in September of 2020. Now, a team of scientists have shown that domestic sewage monitoring is useful for a foodborne pathogen as well. Read more ›
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Spintronic devices work with spin textures caused by quantum-physical interactions. Scientists have now studied graphene-cobalt-iridium heterostructures at BESSY II. The results show how two desired quantum-physical effects reinforce each other in these heterostructures. This could lead to new spintronic devices based on these materials. Read more ›
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Researchers investigated differences in T-cell responses between male and female patients with lung cancer that may help direct future treatments. T-cell responses are part of the adaptive immune system, which is part of the body's 'smart system' that monitors for threats and fights them with customized defenses. Read more ›
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The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD) despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a new study. Read more ›
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Using MRI scans of almost 1,000 Dutch people, researchers show that there is indeed a connection between brain structure and ideology. However, the connection is smaller than expected. Nevertheless, the researchers find it remarkable that differences in the brain are linked to something as abstract as ideology. Read more ›
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Daniel Capelluto and his research team have discovered the mechanism by which the bacterial pathogen Shigella flexneri, the causative agent of dysentery, manipulates molecular activity to assure its survival against its host's natural defenses. Read more ›
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Researchers have found microplastics less than 300 m in size in coral skeletons. The team developed a new protocol to extract and detect microplastics and applied it to coral samples from the Gulf of Thailand. The finding may also explain the 'missing plastic problem,' where about 70% of plastic in the oceans cannot be found. The corals may act as a 'sink' for microplastics, absorbing them from the marine environment. Read more ›
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Within the cycling realm, 'to Everest' involves riding up and down the same mountain until your ascents total the elevation of Mt. Everest. A new record was set a few years ago, but a debate ensued about the strong tailwind the cyclist had on climbs. To what extent do the tailwind help a cyclist as they climb? Should limits be set on the allowed windspeed? Read more ›
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Researchers used a detailed mathematical model to demonstrate that the construction sector in the UK and Europe could almost eliminate its carbon emissions by 2060. This could be achieved through using state-of-the-art energy efficiency technologies to renovate existing properties and construct new ones. Read more ›
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01.07.2026 06:29
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