Could it be that one of only three known markers directly targeting the DNA does not exist outside the realm of microbes? Now, researchers have demonstrated that this marker -- N4-methylcytosine (4mC) -- is essential for sperm development and maturation in the liverwort Marchantia polymorpha, a key organism in plant evolution. Read more ›
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Evidence shows that hunter-gatherers were crossing at least 100 kilometers (km) of open water to reach the Mediterranean island of Malta 8,500 years ago, a thousand years before the arrival of the first farmers. Read more ›
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Osteoarthritis is the leading cause of disability and chronic pain worldwide, affecting an estimated 595 million people globally. Projections suggest that this number will rise to 1 billion by 2050. Despite its profound impact on individuals and societies, no disease-modifying treatments are currently available. Now, an international team of researchers has made new discoveries by studying the genetics of osteoarthritis in nearly 2 million individuals, uncovering hundreds of potential new... Read more ›
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Researchers have identified nearly 300 genetic disorders that can be treated before or immediately after a baby is born. This 'treatable fetal findings list' could improve the diagnosis of genetic conditions in pregnancy and enhance the treatment options available for fetuses who have these conditions. Read more ›
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By mapping the subcellular architecture and protein interactions within cells, researchers can better understand how mutations contribute to pediatric cancers and other conditions. Read more ›
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A new study reveals the modern arid desert between Africa and Saudi Arabia was once regularly lush and green with rivers and lakes over a period of 8 million years, allowing for the occupation and movements of both animals and hominins. Read more ›
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Comprehensive reference genomes have now been assembled for six ape species: siamang (a Southeast Asian gibbon), Sumatran orangutan, Bornean orangutan, gorilla, bonobo and chimpanzee. Areas of their genomes previously inaccessible because of structural complexity have now mostly been resolved. The resource is already lending itself to comparative studies that offer new insights into human and ape evolution, and into what underlies the functional differences among these species. Read more ›
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Preparing catalysts by sending hot, steamy car exhaust over them could improve their efficiency and reduce the amount of rare and expensive metals required in vehicle catalytic converters and many other emission control and industrial processes. Read more ›
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Rsearchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin. By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more. Read more ›
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Investigators have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing technology -- which is programmed to correct individual mutations... Read more ›
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A research team has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes -- demonstrated successfully in living mouse models that are blind due to a mutation. This system also holds promise for advancing cancer therapy by enabling precise genetic manipulation of. Read more ›
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Scientists have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells. These sugars, called glycans, help cells recognize and communicate with each other. They also act as a cellular 'signature,' with each subtype of pancreatic cancer cell possessing a different composition of glycans. Read more ›
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Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's disease (AD), but its role in the brain was unknown until now. Researchers used preclinical models to uncover Tim-3's role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer's disease. Read more ›
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Scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional pain medications. Read more ›
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When it comes to upgrading electrical and broadband infrastructure, new research shows that a 'dig once' approach is nearly 40% more cost effective than replacing them separately. The study also found that the greatest benefit comes from proactively undergrounding lines that are currently above ground, even if lines haven't reached the end of their usefulness. Read more ›
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About 66 million years ago, an asteroid slammed into the planet, wiping out all non-avian dinosaurs and about 70% of all marine species. But the crater it left behind in the Gulf of Mexico was a literal hotbed for life enriching the overlying ocean for at least 700,000 years, according to new research. Read more ›
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Researchers report their discovery of fluorescent pigments in the feathers of Long-eared Owls, that can only be seen by humans with the help of ultraviolet light. Read more ›
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Scientists have pioneered an influenza virus vector-based nasal spray vaccine platform and developed a nasal spray H5N1 avian influenza vaccine. During the early COVID-19 pandemic, this platform enabled the rapid development of a nasal spray vaccine in collaboration with mainland China's Wantai BioPharm. After completing Phase 1-3 clinical trials, it was approved in 2022 as the world's first nasal spray COVID-19 vaccine. Read more ›
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Researchers conducted a large-scale epidemiological study to explore the potential health benefits of high muscle strength in preventing type 2 diabetes (T2D) across varying levels of genetic risk. The study found that higher muscle strength was associated with over 40% lower risk of T2D, regardless of genetic susceptibility to T2D. The study highlights the importance of maintaining or improving muscle strength as a key strategy for preventing T2D. Read more ›
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Researchers explored the long-term effects of preschool expansion in Japan in the 1960s, revealing significant reductions in risky behaviors amongst teenagers. By analyzing regional differences in the rollout of the program, the study identified links between early childhood education and lower rates of juvenile violent arrests and teenage pregnancy. The findings suggest that improved noncognitive skills played a key role in mitigating risky behaviors, highlighting the lasting benefits of early-education... Read more ›
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16.06.2026 09:10
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